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. 2015 Dec 30;113(2):E137–E145. doi: 10.1073/pnas.1517288113

Fig. 2.

Fig. 2.

The docking poses of CAPS and RTX, determined in the TRPV1–CAPS and TRPV1–RTX complexes, respectively, and then pasted in the other two structures. (A) CAPS in the apo potein. A loose binding is observed inside the shallow binding pocket. (B) CAPS in the TRPV1–CAPS complex. (C) CAPS in TRPV1–RTX. The methoxy group of CAPS clashes with the deep pocket. (D) RTX in the apo protein. The aromatic head group of RTX clashes with the deep subpocket. (E) RTX in the TRPV1–CAPS complex. The aromatic head group and the diterpene moiety clash with the vanilloid pocket. (F) RTX in the TRPV1–RTX complex. RTX fits well inside the binding pocket.