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Water mapping of the TRPV1–CAPS complex. (A) Important water cluster with the putative orientation of individual water molecules. Note in particular the structural waters close to Glu-570. (B) Regions of space with large putative occupancy of uncharged water are represented in red, whereas the ones accommodating canonical waters are shown in yellow. (C) van der Waals region (green) is located close to nonpolar regions.
