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The interaction profile of TRPV1 modulators with the TRPV1 apo structure. Favorable interactions are shown in green and unfavorable ones in red. The docked poses (y axis) are clustered based on their contacts with the commonly interacting amino acids (x axis). (Left) Clustered interaction profiles of the ensemble of ligands. (Right) Zoom on a small cluster of six compounds, and their docking poses in the vanilloid pocket.
