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. Author manuscript; available in PMC: 2016 Mar 3.
Published in final edited form as: Nature. 2015 Aug 10;525(7567):109–113. doi: 10.1038/nature14670

Figure 2. Zebrafish Dchs1b Is Required For AV Canal Development.

Figure 2

(A) By 72 hpf, zebrafish hearts develop a constriction in the atrioventricular canal (AVC) that separates the atrium (a) from the ventricle (v). (B) Knockdown of dchs1b results in absence of the AV constriction (bracket). (C) ~75% of Dchs1b morphants exhibit AVC defects (*p= 1×10−62). DCHS1 human mRNA rescues the dchs1b morpholino AVC phenotype whereas human mutant DCHS1 mRNA (P197H/R2513H) fails to rescue (**p=.009). Total number of fish analyzed was 611 and statistical values were obtained using Fisher’s Exact test.