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. 2016 Jan 20;11(1):e0144215. doi: 10.1371/journal.pone.0144215

Fig 3. Blood-brain barrier permeabilization during polymicrobial sepsis is independent of endothelial MyD88.

Fig 3

CLP or Sham laparotomy was performed in mice of the indicated genotypes. 24 hours later, transcranial 2-photon imaging was performed in vivo. At t = 0, two distinctly labeled dextrans of low and high molecular were injected i.v.: FITC-dextran, 2 MDa, and CascadeBlue-dextran, 10KDa. Imaging was performed over the following 60 min. Images shown are maximal intensity z-stack projections of 30 images acquired in 1 μm steps starting 30–40 μm below the pia. Time denotes the time of initiation of image acquisition. Scale bar, 50 μm.