Table 3. Women with normal cytology and at least one positive HPV test result at baseline: 1.5-year follow-up, persistence of infection, and final histology after repeated testing as per study protocol, by screening test.
| Screening test | Cytology normal and HPV positive at baseline | Women with persistent infections/ incident abnormal cytology | |||
|---|---|---|---|---|---|
| Total | With 1.5-year follow-up (%) | N (% of those with follow-up) | ≥CIN2 (% of those with persistent infection) | ≥CIN3 (% of those with persistent infection) | |
| Cytology | 560a | 214 (38%) | 18 (8%)b | 6 (33%) | 4 (22%) |
| HC2 | 250 | 97 (39%) | 46 (47%) | 7 (15%) | 4 (9%) |
| cobas | 386 | 140 (36%) | 68 (49%)c | ≥9 (13%)d | ≥6 (9%)d |
| CLART | 377 | 147 (39%) | 52 (35%)c | ≥9 (17%)d | ≥6 (12%)d |
| APTIMA | 200 | 65 (33%) | 24 (37%) | ≥6 (25%)d | ≥3 (13%)d |
Abbreviations: CIN = cervical intraepithelial neoplasia, HC2 = Hybrid Capture 2, HPV = Human Papillomavirus.
a Positive test result on any of the four HPV assays.
b Two women had inadequate cytology.
c 65/68 (96%) of women with a persistent infection on cobas had HPV genotypes detected on the same channel; 46/52 (88%) of women with a persistent infection on CLART had at least one high-risk genotype detected both at baseline and at 18-month follow-up.
d Only women with abnormal cytology and/or a positive HC2 test result were referred for colposcopy.