Table S4.
Data Abstraction table B: Treatment outcomes (48 data sets).
| Reference numbers | Sample size of treated pan susceptible pulmonary TB and all forms of resistance except MDR-TB (N) | N treated with each regimen | Treatment outcomes | Remarks | ||||
|---|---|---|---|---|---|---|---|---|
| Completed | Not completed | |||||||
| Success (cured and completed) | Failed | Died | Relapsed | Defaulted | ||||
| [1] | 105 | 57 | 25 | 7 | 7 | 1 | 18 | Total on FDC 57 |
| 48 | 25 | 4 | 2 | 0 | 16 | Total on separate formulation 48 | ||
| [2] | 67 | 67 | 58 | 3 | 0 | 6 | 0 | 67 patients on 2EHRZ/4RH |
| [3] | 1355 | 456 | 231 | 47 | 17 | 20 | 74 | The study included some HIV positives. |
| 466 | 248 | 32 | 9 | 30 | 89 | |||
| 433 | 249 | 36 | 12 | 9 | 74 | |||
| [4] | 146 | 39 | 39 | 0 | 0 | 0 | 0 | |
| [5] | 1585 | 798 | 591 | 19 | 8 | 48 | 9 | 39 on FDC and 38 patients on separate drugs were HIV positive. |
| 787 | 589 | 16 | 8 | 42 | 1 | |||
| [6] | 837 | 415 | 347 | 32 | 26 | 0 | 27 | |
| 422 | 320 | 27 | 21 | 0 | 55 | |||
| [7] | 198 | 198 | 193 | 0 | 0 | 4 | 0 | 67 of 198 patients were smear negative |
| [8] | 360 | 162 | 152 | 5 | 2 | 0 | 2 | Two patients on NTP regimen excluded due jaundice are reflected under TO |
| 198 | 188 | 8 | 3 | 0 | 1 | |||
| [9] | 520 | 175 | 171 | 2 | 1 | 1 | 0 | |
| 174 | 171 | 1 | 1 | 2 | 0 | |||
| 171 | 161 | 3 | 3 | 2 | 0 | |||
| [10] | 100 | 34 | 26 | 2 | 0 | 0 | 4 | |
| 34 | 26 | 0 | 0 | 0 | 6 | |||
| 32 | 24 | 2 | 0 | 0 | 6 | |||
| [11] | 122 | 61 | 44 | 4 | 2 | 0 | 5 | |
| 61 | 53 | 2 | 0 | 0 | 4 | |||
| [12] | 141 | 141 | 127 | 0 | 1 | 4 | 0 | |
| [13] | 1159 | 582 | 468 | 24 | 11 | 7 | 43 | FDC |
| 577 | 477 | 16 | 4 | 4 | 41 | ST | ||
| [14] | 467 | 450 | 393 | 33 | 4 | 20 | 0 | |
| [15] | 825 | 305 | 279 | 11 | 0 | 15 | 0 | 112 patients excluded due to ineligibility |
| 263 | 234 | 1 | 0 | 28 | 0 | |||
| [16] | 170 | 165 | 144 | 5 | 1 | 10 | 2 | |
| [17] | 497 | 170 | 113 | 7 | 6 | 0 | 46 | |
| 165 | 103 | 7 | 7 | 0 | 53 | |||
| 162 | 105 | 3 | 3 | 0 | 53 | |||
| [18] | 434 | 236 | 208 | 12 | 3 | 10 | 4 | FDC-119 have no bacteriological follow up data |
| 198 | 179 | 7 | 3 | 2 | 4 | Loose drugs-108 have no bacteriological follow up data | ||
| [19] | 168 | 61 | 61 | 6 | 0 | 0 | 0 | Detailed outcomes not given for all patients by regimen |
| 58 | 58 | 20 | 0 | 0 | 0 | |||
| [20] | 1240 | 407 | 338 | 37 | 0 | 32 | 0 | A third of included in the analysis were previously treated. |
| 415 | 363 | 26 | 0 | 26 | 0 | |||
| 418 | 334 | 48 | 0 | 36 | 0 | |||
| [21] | 188 | 188 | 171 | 5 | 0 | 10 | 2 | |
| [22] | 399 | 199 | 193 | 1 | 0 | 5 | 0 | 64 of drug sensitive and 13 of drug resistant had previous chemotherapy |
| 200 | 199 | 0 | 0 | 1 | 0 | |||
| [23] | 98 | 87 | 86 | 1 | 0 | 0 | 0 | 32 patients were HIV positive |
| [24] | 88 | 88 | 87 | 0 | 0 | 1 | 0 | |
| [25] | 156 | 156 | 106 | 12 | 2 | 4 | 12 | Rifampicin group |
| 142 | 142 | 102 | 5 | 2 | 5 | 12 | Rifabutin group | |
| [26] | 102 | 102 | 97 | 1 | 0 | 4 | 0 | |
| [27] | 67 | 67 | 67 | 0 | 0 | 0 | 0 | |