Table 8.

Summary of all lifespan data for mianserin.

DOI: http://dx.doi.org/10.7554/eLife.08833.028

Cumulative statistics							Statistics of individual expts.
Strain	Small molecule	No. of expts.	Mean lifespan [days] (+Mia/+water)	change in lifespan [%]	S.E.M.	No. of animals (+Mia/+water)	Mean lifespan (days) (+Mia/+water)	change in lifespan [%]	P-value	No. of animals (+Mia/+water)
N2	Mia	12	26.7/19.8	+35	± 7	642/577	26.4/19.8	+34	1.67E-08	77/59
							25.5/21.5	+19	6.85E-07	113/94
							28.1/20.1	+40	3.71E-14	95/104
							30.6/19.0	+64	3.17E-15	57/50
							26.8/21.5	+25	1.87E-11	149/145
							22.6/16.6	+27	1.61E-23	151/125
snt-1 (md290)	Mia	3	20.9/18.2	+15	± 2	236/231	23.3/19.9	+17	1.84E-05	86/90
							17.3/15.4	+12	1.18E-02	79/80
							22.1/19.3	+15	2.4E-03	71/61
unc-26 (e205)	Mia	3	25.0/26.7	-7	± 7	135/165	27.8/26.9	+3	0.53	54/68
							22.2/26.5	-16	4.52E-02	14/24
							26.5/25.3	+5	0.52	67/73
ser-5 (ok3087)	Mia	3	23.4/22.2	+5	± 5	496/458	23.6/20.6	+15	4.19E-02	152/144
							26.4/26.2	+1	0.85	174/144
							20.1/19.8	-1	0.25	170/170

Summary of all lifespan experiments performed in Figure 5e,f and Figure 5—figure supplement 1a. N2 and mutant strains were treated with 50 µM mianserin (Mia) on day 1 and lifespan [days] was scored until 95% of animals were dead in all tested conditions. Cumulative statistics and statistics of individual experiments are shown. Mean lifespan [days], change in lifespan [%] and S.E.M. for mianserin-treated (+Mia) and water-treated (+water) animals from multiple, independent experiments (expts.) are shown. Change in lifespan [%] and P-values for individual experiments were calculated using the Mantel–Haenszel version of the log-rank test. Number of animals in individual experiments and all experiments combined are shown.