Table II.
Gene-Environment Set Associations Tests (GESAT) interaction results for chronic burden × region and social support × region
| Chronic Burden | Social Support | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Region | AA | EA | CA | HA | Fisher's | AA | EA | CA | HA | Fisher's | ||
| p | p | p | p | χ2 (df) | χ2 p | p | p | p | p | χ2 (df) | χ2 p | |
| 1 | 9.91E-01 | 6.93E-02 | 3.53E-02 | 6.96E-01 | 12.8 (8) | 0.12 | 3.25E-01 | 9.65E-01 | 3.69E-01 | 7.14E-01 | 5.0 (8) | 0.76 |
| 2 | 7.61E-01 | 3.18E-01 | 3.94E-01 | 7.82E-01 | 5.2 (8) | 0.74 | 9.22E-01 | 8.95E-01 | 6.97E-01 | 6.86E-01 | 1.9 (8) | 0.99 |
| 3 | 7.64E-01 | 4.10E-01 | 8.35E-01 | 6.98E-01 | 3.4 (8) | 0.91 | 7.73E-01 | 5.50E-01 | 5.00E-01 | 8.70E-01 | 3.4 (8) | 0.91 |
| 4 | 3.20E-01 | 6.93E-01 | 9.20E-01 | 9.51E-01 | 3.3 (8) | 0.92 | 3.89E-01 | 7.61E-01 | 4.19E-01 | 9.88E-01 | 4.2 (8) | 0.84 |
| 5 | 1.73E-01 | 5.58E-01 | 9.03E-01 | 9.66E-01 | 4.9 (8) | 0.76 | 6.87E-01 | 7.63E-01 | 4.28E-01 | 9.67E-01 | 3.1 (8) | 0.93 |
| 6 | 1.95E-01 | 6.10E-01 | 8.54E-01 | 9.50E-01 | 4.7 (8) | 0.79 | 5.46E-01 | 7.82E-01 | 7.40E-01 | 9.60E-01 | 2.4 (8) | 0.97 |
| 7 | 1.27E-01 | 3.58E-01 | 5.32E-01 | 6.80E-01 | 8.2 (8) | 0.41 | 3.67E-01 | 3.73E-01 | 3.42E-01 | 5.34E-02 | 12.0 (8) | 0.15 |
| 8 | 3.41E-01 | 6.46E-01 | 6.10E-01 | 5.72E-01 | 5.1 (8) | 0.74 | 1.91E-01 | 5.73E-01 | 3.55E-01 | 2.83E-02 | 13.6 (8) | 0.09 |
| 9 | 1.57E-01 | 1.33E-01 | 1.43E-01 | 5.71E-01 | 12.7 (8) | 0.12 | 2.09E-01 | 2.51E-01 | 1.82E-01 | 6.78E-01 | 10.1 (8) | 0.26 |
| 10 | 4.62E-01 | 6.41E-01 | 4.93E-01 | 5.95E-01 | 4.9 (8) | 0.77 | 4.75E-01 | 9.23E-01 | 7.62E-01 | 1.74E-01 | 5.7 (8) | 0.68 |
| 11 | 4.69E-01 | 3.28E-01 | 3.70E-01 | 2.40E-01 | 8.6 (8) | 0.38 | 8.98E-01 | 8.61E-01 | 9.95E-01 | 9.86E-01 | 0.6 (8) | 1.00 |
| 13 | 1.85E-01 | 3.21E-01 | 2.63E-01 | 1.27E-02 | 17.1 (8) | 0.03 | 6.40E-02 | 4.06E-01 | 2.15E-01 | 9.78E-01 | 10.4 (8) | 0.24 |
| 14 | 5.52E-01 | 3.45E-01 | 9.77E-02 | 8.59E-01 | 8.3 (8) | 0.41 | 6.63E-01 | 6.88E-02 | 5.79E-01 | 9.08E-01 | 7.5 (8) | 0.49 |
| 16 | 2.91E-01 | 4.50E-01 | 6.68E-01 | 3.88E-01 | 6.8 (8) | 0.56 | 4.27E-01 | 3.69E-01 | -- | 7.12E-01 | 4.4 (6) | 0.63 |
| 17 | 3.62E-01 | -- | 1.81E-01 | 5.45E-01 | 6.7 (6) | 0.35 | 6.37E-01 | 4.53E-01 | 2.90E-01 | 7.30E-01 | 5.6 (8) | 0.69 |
| 19 | 9.54E-01 | 7.82E-01 | 5.03E-01 | 2.86E-01 | 4.5 (8) | 0.81 | 1.55E-01 | 4.13E-02 | 8.99E-01 | 9.91E-01 | 10.3 (8) | 0.24 |
| 20 | 1.75E-01 | 3.10E-01 | 6.17E-01 | 6.15E-01 | 7.8 (8) | 0.46 | 2.41E-01 | 2.89E-01 | 3.12E-01 | 7.64E-01 | 8.2 (8) | 0.41 |
| 21 | 5.33E-01 | 8.92E-01 | 1.24E-01 | 8.89E-01 | 5.9 (8) | 0.66 | 9.43E-01 | 8.37E-01 | 7.78E-01 | 8.00E-01 | 1.4 (8) | 0.99 |
| 22 | 5.57E-01 | 6.42E-01 | 7.20E-01 | 1.87E-01 | 6.1 (8) | 0.64 | 2.69E-01 | 4.34E-01 | 8.66E-01 | 2.73E-01 | 7.2 (8) | 0.52 |
| 23 | 6.51E-01 | 9.66E-01 | 2.91E-01 | 4.12E-01 | 5.2 (8) | 0.74 | 5.67E-01 | 4.28E-01 | 6.56E-01 | 9.19E-01 | 3.8 (8) | 0.87 |
| 24 | 6.87E-01 | 4.45E-01 | 2.29E-01 | 6.67E-01 | 6.1 (8) | 0.63 | 8.18E-01 | 7.81E-01 | 7.50E-01 | 5.25E-01 | 2.8 (8) | 0.95 |
| 26 | 7.65E-01 | 7.75E-01 | 7.49E-01 | 4.42E-01 | 3.3 (8) | 0.92 | 6.06E-01 | 5.26E-02 | 9.44E-01 | 2.49E-01 | 9.8 (8) | 0.28 |
| 27 | 6.32E-01 | 8.78E-01 | 8.40E-01 | 4.30E-01 | 3.2 (8) | 0.92 | 4.82E-01 | 8.63E-02 | 9.44E-01 | 2.50E-01 | 9.2 (8) | 0.32 |
| 28 | 5.62E-01 | 7.60E-01 | 2.28E-01 | 4.98E-01 | 6.1 (8) | 0.64 | 3.37E-01 | 1.72E-01 | 7.52E-01 | 4.59E-01 | 7.8 (8) | 0.45 |
| 29 | 3.81E-01 | 7.51E-01 | 5.90E-01 | 4.25E-01 | 5.3 (8) | 0.73 | 4.19E-02 | 4.20E-02 | 3.99E-01 | 9.08E-01 | 14.7 (8) | 0.06 |
| 30 | 6.67E-01 | 5.84E-01 | 4.62E-01 | 2.40E-01 | 6.3 (8) | 0.62 | 4.98E-01 | 9.20E-01 | 9.05E-01 | 9.62E-01 | 1.8 (8) | 0.99 |
| 32 | 7.93E-02 | 6.63E-01 | 6.07E-01 | 9.51E-01 | 7.0 (8) | 0.54 | 1.68E-01 | 8.85E-01 | 5.84E-01 | 9.72E-01 | 4.9 (8) | 0.76 |
| 33 | 5.12E-01 | 6.52E-01 | 4.92E-01 | 1.74E-01 | 7.1 (8) | 0.52 | 1.53E-01 | 7.13E-01 | 3.16E-01 | 2.56E-01 | 9.5 (8) | 0.30 |
| 34 | 6.98E-01 | 1.26E-01 | 5.31E-01 | 2.90E-01 | 8.6 (8) | 0.38 | 9.02E-01 | 2.18E-01 | 1.02E-01 | 5.54E-01 | 9.0 (8) | 0.34 |
| 35 | 1.34E-01 | 9.77E-01 | 4.25E-01 | 7.62E-01 | 6.3 (8) | 0.61 | 8.64E-01 | 9.12E-01 | 3.43E-01 | 7.91E-01 | 3.1 (8) | 0.93 |
| 38 | 8.42E-01 | 7.33E-01 | 9.18E-02 | 5.40E-01 | 7.0 (8) | 0.54 | 8.92E-01 | 9.65E-01 | 4.38E-01 | 2.57E-02 | 9.3 (8) | 0.32 |
| 40 | 8.45E-01 | 4.14E-01 | 2.11E-01 | 2.10E-01 | 8.3 (8) | 0.40 | 1.04E-01 | 9.94E-01 | 6.35E-01 | 6.47E-01 | 6.3 (8) | 0.61 |
| 41 | 9.65E-01 | 5.94E-01 | 5.25E-01 | 2.28E-01 | 5.4 (8) | 0.72 | 5.29E-01 | 9.08E-01 | 4.44E-01 | 7.26E-01 | 3.7 (8) | 0.88 |
| 42 | 2.11E-01 | 4.60E-01 | 1.89E-01 | 3.83E-01 | 9.9 (8) | 0.27 | 2.67E-01 | 6.96E-01 | 3.62E-01 | 7.62E-01 | 5.9 (8) | 0.65 |
| 43 | 6.09E-01 | 5.35E-01 | 7.45E-01 | 1.24E-01 | 7.0 (8) | 0.54 | 1.10E-01 | 5.01E-01 | 8.86E-01 | 8.45E-01 | 6.4 (8) | 0.61 |
| 44 | 5.95E-01 | 6.46E-02 | 9.17E-02 | 6.42E-01 | 12.2 (8) | 0.14 | 5.78E-01 | 8.73E-01 | 6.79E-01 | 9.88E-02 | 6.8 (8) | 0.56 |
| 46 | 7.61E-01 | 7.12E-01 | 6.51E-01 | 9.15E-01 | 2.3 (8) | 0.97 | 7.23E-01 | 4.94E-01 | 7.55E-01 | 7.84E-01 | 3.1 (8) | 0.93 |
AA: African Americans, EA: European Americans, CA: Chinese Americans, HA: Hispanic Americans, p: p-value
Only regions with MetaSKAT p-value <0.20 were investigated in the interaction analysis.
-- Indicates a model that did not converge, Fisher's combined p-values ≤ 0.05 are bolded