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. 2015 Nov 30;13(1):226–236. doi: 10.1007/s13311-015-0407-1

Fig. 3.

Fig. 3

Vascular endothelial growth factor (VEGF) inhibition results in an upregulation of VEGF expression within gliomas. (A, B) Administration of aflibercept (n = 12 mice) results in a significant upregulation of VEGF expression within the tumor environment compared with phosphate-buffered saline (PBS)-treated controls (n = 15 mice). Images were acquired using a 63× objective. Scale bar = 40 μm. ***p < 0.001