Table 1.
Patient demographics and characteristics
| Number of subjects | 81 |
|---|---|
| Total number of observations | |
| R-citalopram | 205 (2.5 observation/subject) |
| R-desmethylcitalopram | 179 (2.2 observation/subject) |
| S-citalopram | 205 (2.5 observation/subject) |
| S-desmethylcitalopram | 109 (1.3 observation/subject) |
| Sex | |
| Male | 41 (50.6 %) |
| Female | 40 (49.4 %) |
| Age, years, mean ± SD (range) | 77.8 ± 8.2 (47–90) |
| Weight, kg, mean ± SD (range) | 71.5 ± 17.2 (40–122.3) |
| Body mass index, lbs/in2, mean ± SD (range) | 26.3 ± 5.2 (15.4–41.6) |
| CYP2C19 genotype | |
| Extensive metabolizers | 43 (53.1 %) |
| Rapid metabolizers | 3 (3.7 %) |
| Intermediate metabolizers | 17 (21 %) |
| Poor metabolizers | 3 (3.7 %) |
| Missing | 15 (18.5 %) |