Table 2.
Covariate selection for final model
| Model | −2LL | ∆ −2LL | df | p valuea | |
|---|---|---|---|---|---|
| Univariate forward selection | |||||
| R-enantiomer | Base | 1465.08 | |||
| CLRp | Added age | 1449.53 | −15.55 | 1 | 8.03E−5 |
| Added sex | 1434.19 | −15.34 | 1 | 8.99E−5 | |
| Full parent model + base metabolite model | 2361.97 | ||||
| CLRm | Added weight | 2335.72 | −26.25 | 1 | 3.00E−7 |
| S-enantiomer | Base | 1330.84 | |||
| LSp | Added weight | 1319.60 | −11.24 | 1 | 8.00E−4 |
| Added age | 1310.87 | −8.73 | 1 | 0.003 | |
| Added CYP2C19 genotype | 1301.93 | −8.94 | 2 | 0.01 | |
| Full parent model + base metabolite model | 1743.85 | ||||
| CLSm | Added weight | 1721.89 | −21.96 | 1 | 2.78E−6 |
| Stepwise backward elimination | |||||
| R,S-enantiomers | Final model | 4052.32 | |||
| CLRp | Removed age | 4070.12 | 17.8 | 1 | 2.5E−5 |
| Removed sex | 4070.56 | 18.24 | 1 | 1.9E−5 | |
| CLRm | Removed weight | 4084.99 | 32.67 | 1 | 1.0E−8 |
| CLSp | Removed weight | 4059.46 | 7.14 | 1 | 7.5E−3 |
| Removed age | 4067.82 | 15.5 | 1 | 8.3E−5 | |
| Removed CYP2C19 genotype | 4061.49 | 9.17 | 2 | 0.01 | |
| CLSm | Removed weight | 4078.95 | 26.63 | 1 | 2.5E−7 |
aCalculated at 0.05 significance level