Table 1.
Characteristics of the 200 women with breast cancer relative to their rs11515 genotype.
| Characteristic | rs11515 genotype |
Significance | ||
|---|---|---|---|---|
| CC (n = 121) | CG (n = 76) | GG (n = 3) | ||
| Age at surgery years | 58.2 (55.6–60.7) | 63.3 (60–66.5) | 30.3 (14.1–46.5) | 0.0001 |
| Tumor grade | ||||
| 1 | 17 (15.2%) | 9 (11.8%) | 3 (100%) | ns |
| 2 | 42 (37.5%) | 34 (44.7%) | ||
| 3 | 53 (47.3%) | 33 (43.4%) | ||
| Not known | 9 | |||
| Lymph/vascular invasion present | 37 (30.6%) | 38 (50%) | 1 (33.3%) | ns |
| Tumor size (mm) | 24.2 (21–27.3) | 26.4 (22.5–30.4) | 38.3 (18.8–57.9) | ns |
| Metastases to lymph nodes | ||||
| None | 73 (60.3%) | 29 (38.2%) | 1 (33.3%) | 0.007 |
| 1 node | 23 (19%) | 13 (17.1%) | 1 (33.3%) | |
| ≥2 nodes | 25 (20.7%) | 34 (44.7%) | 1 (33.3%) | |
| Estrogen Receptor | ||||
| Negative | 34 (30.4%) | 20 (26.3%) | 1 (33.3%) | ns |
| Positive | 72 (64.3%) | 52 (68.4%) | 2 (66.7%) | |
| Equivocal | 6 (5.4%) | 4 (5.3%) | ||
| Data not known | 10 | 0 | ||
| Progesterone receptor | ||||
| Negative | 47 (42%) | 31 (40.8%) | 1 (33.3%) | ns |
| Positive | 56 (50%) | 37 (48.7%) | 2 (66.7%) | |
| Equivocal | 9 (8%) | 8 (10.5%) | ||
| Data not known | 9 | 0 | ||
| HER2 receptor | ||||
| Negative | 30 (58.8%) | 24 (75%) | 2 (66.7%) | ns |
| Positive | 16 (31.4%) | 8 (25%) | 1 (33.3%) | |
| Equivocal | 5 (9.8%) | 0 | ||
| Data not known | 69 | 44 | ||
Results are the mean (95% confidence intervals), or the n value (percent positive).
P values represent the comparison between three genotypes.
ns, not significant.