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. 2016 Jan 21;9:520. doi: 10.3389/fnins.2015.00520

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Copyright © 2016 Bojić, Perović and Glišić.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic presentation of the EIIP/AQVN criterion for selection of candidate antimuscarinic drugs with potential therapeutic effect on VVS. Active domain (red): AQVN (2.25–2.65), EIIP (0.074–0.096). Chemical space (blue) AQVN (2.40–3.30) EIIP (0.000–0.116) EIIP/AQVN domain of homologous distribution of >90% compounds from PubChem Compound Database. Statistics: inside the active domain: 21 (78%), outside the active domain: 6 (22%). Asterisk (^*)-position of atropine and propentheline bromide, known anti VVS drugs, within AQVN/EIIP active domain.