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Proposed mechanism of antagonizing effect of apeline-MAS receptor and Angiotensin II-ATR1 molecular signaling pathways on preganglionic sympathetic neurons in the brainstem (adapted from Northrup and Erickson 1992.) Ang II, angiotensin II; ATR1, angiotensin 1 receptor; MAS R, MAS receptor; O2, superoxide; NO, nitric oxide; nNOS, neural nitric oxide synthase; SNA, sympathetic nervous activity; MAP, mean arterial pressure.
