Table 1.

EIIP/AQVN values of patented muscarinic modulators: Muscarinic modulators (US Patent 7786308), Muscarinic agonists (US Patent 7378447), and Modulators of muscarinic receptors (US Patent Application 20100311746A1).

EIIP [RY]	AQVN	Chemical formula	Compound
Patent title: Muscarinic modulators (US Patent 7786308
0.0845	2.590	C23H31FN2O4	ethyl 3-(4-(4-fluorophenyl)(methoxycarbonyl) amino)piperidin-1-yl)-8-azabicyclo[3.2.1]octane-8-carboxylate
0.0886	2.562	C23H33FN4O3	3-{4-[1-(4-Fluoro-phenyl)-3,3-dimethyl-ureido]-piperidin-1-yl}-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid ethyl ester
0.0946	2.500	C27H38FN3O3	3-{4-[Cyclohexanecarbonyl-(4-fluoro-phenyl)-amino]-piperidin-1-yl}-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid ethyl ester
0.0985	2.444	C23H35N3O2	3-[4-(ethyl-phenyl-amino)-piperidin-1-yl]-8-azabicyclo[3.2.1]octane-8-carboxylic acid ethyl ester
0.0899	2.552	C21H30FN3O3	4-[Acetyl-(4-fluoro-phenyl)-amino]-[1,4′]bipiperidinyl-1′-carboxylic acid ethyl ester
Patent title: Muscarinic agonists (US Patent 7378447)
0.0985	2.618	C19H29N3O4	Carbamic acid tert-butyl ester (R)-(6-(1-(morpholin-4-yl)ethylideneamino)-2(R)-hydroxyindan-1-yl)amide
0.0963	2.431	C22H36BrN3O3	Biphenyl-4-carboxylic acid (R)-(6-(1-(2-methoxyethyl)methylamino)ethylideneamino)-2(R)-hydroxyindan-1-yl)amide
0.0863	2.579	C31H39N3O3	Biphenyl-1-carboxylic acid (R)-(6-(1-(2-pentoxyethyl)methylamino)ethylideneamino)-2(R)-hydroxyindan-1-yl)amide
0.0958	2.622	C31H37N3O3	Biphenyl-4-carboxylic acid (R)-(6-(1-(2-tert-butoxyethyl)methylamino)ethylideneamino)-2(R)-hydroxyindan-1-yl)amide
Patent title: Modulators of muscarinic receptors (US Patent Application 20100311746A1)
0.0758–0.0985	2.390–2.638		1041 compounds