Table 3. Clinical and Imaging Variables Associated with Progression-Free Survival and Overall Survival in Patients with Glioblastoma.
| Variables | Progression-Free Survival | Overall Survival | ||
|---|---|---|---|---|
| Hazard Ratio (95% CI) | P | Hazard Ratio (95% CI) | P | |
| Age, years | 0.99 (0.98-1.01) | 0.57 | 1.01 (0.99-1.03) | 0.21 |
| Male gender | 0.80 (0.53-1.21) | 0.20 | 0.87 (0.54-1.38) | 0.55 |
| KPS score | 1.04 (1.01-1.07) | 0.003 | 1.00 (0.97-10.3) | 0.92 |
| Preoperative tumor size, cm3 | 0.98 (0.95-1.01) | 0.14 | 1.01 (0.98-1.04) | 0.61 |
| Biopsy (vs. partial tumor resection) | 1.44 (0.90-2.33) | 0.13 | 0.99 (0.60-1.65) | 0.99 |
| Postoperative tumor size, cm3 | 1.04 (1.01-1.08) | 0.02 | 0.99 (0.96-1.03) | 0.83 |
| Radiation dose at CCRT, Gy | 0.93 (0.84-1.03) | 0.16 | 1.01 (0.90-1.13) | 0.93 |
| Skewness/kurtosis group 2 (vs. group 1) | 2.98 (1.56-5.67) | < 0.001 | 1.51 (0.78-2.93) | 0.22 |
| Skewness/kurtosis group 3 (vs. group 1) | 4.38 (2.12-9.05) | < 0.001 | 1.93 (0.90-4.15) | 0.10 |
| Skewness/kurtosis group 4 (vs. group 1) | 4.64 (2.18-9.92) | < 0.001 | 2.06 (0.97-4.37) | 0.06 |
CCRT = concurrent chemoradiotherapy, CI = confidence interval, KPS = Karnofsky performance scale