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. 2015 Dec 31;6(12):e2034. doi: 10.1038/cddis.2015.355

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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BIRD-2/ABT-263 synergy. (a–c) SCLC lines were treated with BIRD-2, ABT-263, or 127 : 1 BIRD-2+ABT-263 as in Figure 1g, with cell viability determined by CTG assay. Error bars represent mean±S.D.; N≥3 experiments. Asterisk designates Chou–Talalay CI calculated using the CompuSyn software, where CI<1 indicates synergy. (d–f) Normalized isobolograms for BIRD-2+ABT-263 combinations with plots generated using the CompuSyn software. Each symbol represents a unique combination of a given concentration of ABT-263 and a given concentration of BIRD-2. Symbols below the line indicate synergistic cytotoxicity; symbols on the lines indicate additive cytotoxicity; symbols above the lines indicate antagonism