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. 2015 Dec 31;6(12):e2034. doi: 10.1038/cddis.2015.355

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Biochemical evidence of apoptosis induction by BIRD-2. (a) Flow cytometry of Annexin V and propidium iodide–stained H2171 SCLC cells following treatment with 20 μM BIRD-2 or Scr for 1 h. (b) Bar graphs (mean±S.D., three experiments) quantifying the percentage of cells, treated, and analyzed as in panel (a), which are Annexin V positive but propidium iodide negative. (c) Quantification of caspase 3/7 activity in H2171-RFP cells by IncuCyte ZOOM at various time points following addition of 20 μM BIRD-2 or Scr. (d) Measurements of nuclear area in H2171-RFP cells treated as in panel (c). Error bars represent mean±S.D., N≥3 experiments. *P<0.05. **P<0.01