Figure 2.
PrPc induces sustained neuroprotection after focal cerebral ischemia. (a) Infarct volume determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining and (b) neuronal density determined by NeuN immunohistochemistry in the striatum in WT, PrP−/− and PrP+/+ mice exposed to 45 min MCA occlusion followed by 24 h (in a) or 28 days (in b) reperfusion. Representative photographs are also shown, which in (b) were taken in the core of the ischemic striatum. Scale bars: 20 μm. *Significantly different from WT mice, P<0.05. #Significantly different from PrP−/− or PrP+/+ mice, P<0.05