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. 2015 Aug 18;21(2):243–251. doi: 10.1038/mp.2015.110

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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(a) Illustrates volunteers' positive and negative affect schedule (PANAS) negative affect subscale scores at each of three time points (baseline, after neutral induction and after sadness induction) across all study subjects. (b) Illustrates the effect of diagnosis (healthy control vs major depressive disorder (MDD)) on mood-induced changes in PANAS negative affect subscale scores, healthy controls clustered on the left and MDD volunteers clustered on the right. Order of neutral and sustained sadness states were randomized and counterbalanced.