Table 1. Shown in the table are brain regions where endogenous opioid neurotransmitter responses to mood induction were associated with concurrent mood-induced changes in plasma IL-18 concentration.

Brain region	MNI coordinates	Z-score
Neutral mood induction: MDDs
Left anterior cingulate cortex	6, 31, 5	3.9
Right anterior cingulate cortex	−11, 36, 11	3.9
Left ventral pallidum	10, 11, −14	4.3
Right hypothalamus	−11, 2, −13	5.0
Left amygdala	17, 6, −22	5.2
Right amygdala	−27, 1, −22	3.6
Neutral mood induction: controls
Right ventral tegmental area	−4, −7, −8	3.8
Sad mood induction: MDDs
Left medial thalamus	2, −17, 4	5.1
Right medial thalamus	−5, −11, 3	5.3
Left ventral pallidum	7, 14, −6	6.0
Left hypothalamus	17, −1, −10	6.7
Right hypothalamus	−10, 0, −12	8.3
Left ventral tegmental area	17, −1, −10	6.7
Right ventral tegmental area	−2, −4, −7	6.3
Left amygdala	19, −4, −18	8.3
Right amygdala	−24, 0, −21	3.8
Sad mood induction: controls
Right ventral tegmental area	−7, 4, −3	5.5
Right hypothalamus	−5, 8, −13	4.3
Left amygdala	22, −3, −24	7.8

Abbreviations: IL-18, interleukin-18; MDD, major depressive disorder.

These data result from analyses within SPM8 (Wellcome Trust) and Matlab (Mathworks, Natick, MA, USA). Relationships during neutral mood induction are shown in the upper half of the table and relationships following sad mood induction are shown in the lower half of the table. Brain regional peaks of significance are listed with their associated stereotactic coordinates (MNI template) and Z-scores of statistical significance. Significance was set to P<0.001 and at least 10 contiguous voxels for regions with a priori hypotheses and was corrected for multiple comparisons for all other regions.