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. Author manuscript; available in PMC: 2016 Jan 21.
Published in final edited form as: Immunity. 2015 Jan 20;42(1):18–27. doi: 10.1016/j.immuni.2015.01.004

Table 2.

CRISPR-Cas systems developed for genome editing and their cognate PAM requirements.

Species PAM References
Streptococcus pyogenes NGG (Hsu et al., 2013)
Streptococcus mutans NGG (van der Ploeg, 2009)
Streptococcus thermophilus (CRISPR3) NGGNG (Deveau et al., 2008; Fonfara et al., 2014; Horvath et al., 2008)
Streptococcus thermophilus (CRISPR1) NNAAAAW (Fonfara et al., 2014)
Campylobacter jejuni NNNNACA (Fonfara et al., 2014)
Neisseria meningitidis NNNNGATT (Hou et al., 2013; Zhang et al., 2013)
Pasteurella multocida GNNNCNNA (Fonfara et al., 2014)
Francisella novicida NG (Fonfara et al., 2014)
Treponema denticola NAAAAN (Esvelt et al., 2013)