Table 1.
SNPs selected for targeted genotyping in NHANES and their previously reported associations.
| rs number (Coded allele) | Nearest gene (Location) | Associated phenotype (Population) | Reported genetic effect (p-value) | PubMed ID |
|---|---|---|---|---|
|
| ||||
| rs2900976 (NR) | DYSF-RPS20P10 (intergenic) | Albumin (Tuscans living in the Chianti region of Italy) | NR (1.4×10-6) | 18464913 |
|
| ||||
| rs10505955 (G) | BCAT1 (intronic) | Albumin (Korculans from Korcula, Croatia) | β = 0.10 (9.5×10-6) | 19260141 |
|
| ||||
| rs10502868 (G) | SLC14A2 (intronic) | Albumin (Korculans from Korcula, Croatia) | β = -0.40 (6.5×10-6) | 19260141 |
|
| ||||
| rs1243400 (NR) | - (chromosome 10) | Albumin, urinary (European Americans from Framingham, MA) | NR (4.8×10-6 based on FBAT) | 17903292 |
|
| ||||
| rs9305354 (NR) | LOC284825 (intergenic) | Albumin, urinary (European Americans from Framingham, MA) | NR (8.4×10-6 based on GEE) | 17903292 |
|
| ||||
| rs12917707 (G) | UMOD (5′ flanking) | Chronic kidney disease Glomerular filtration rate, estimated by serum creatinine (European-descent participants from multiple cohorts) | OR =1.25 (2.3×10-12) | 19430482 |
| β = 0.02 (5.2×10-16) | ||||
|
| ||||
| rs17319721 (A) | SHROOM3 (intronic) | Glomerular filtration rate, estimated by serum creatinine (European-descent participants from multiple cohorts) | β = -0.01 (1.2×10-12) | 19430482 |
|
| ||||
| rs2467853 (G) | SPATA5L1 (intronic) | Glomerular filtration rate, estimated by serum creatinine (European-descent participants from multiple cohorts) | β = -0.01 (6.2×10-14) | 19430482 |
|
| ||||
| rs2032487 (C ) | MYH9 (intronic) | End-stage renal disease, non-diabetic (African Americans) | OR = 2.19 (1.46×10-11, recessive genetic model) | 18794854 |
|
| ||||
| rs4821480 (T) | MYH9 (intronic) | End-stage renal disease, non-diabetic (African Americans) | OR = 2.29 (7.31×10-11, recessive genetic model) | 18794854 |
|
| ||||
| rs4821481 (T) | MYH9 (intronic) | End-stage renal disease, non-diabetic (African Americans) | OR = 2.25 (1.46×10-12, recessive genetic model) | 18794854 |
Abbreviations: beta (β); family-based association tests (FBAT); generalized estimating equations (GEE); not reported (NR); odds ratio (OR).