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. 2016 Jan 20;35:13. doi: 10.1186/s13046-016-0293-3

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© Ge et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — IL-37 negatively regulates tumor angiogenesis. a Immunohistochemistry staining of transplanted tumors of IL-37- and mock-transfected H1299 cells using anti-CD34 antibody. Representative pictures for two groups are shown. b The tumor microvessel density in two groups was counted. c ELISA analysis of VEGF levels in the cultural supernatants of the IL-37 transfected and mock-transfected H1299 cells. d CCK-8 analysis of HUVEC cells cultured in conditioned medium from supernatants of IL-37 or mock transfected H1299 cells. e The effect of IL-37 on the capillary structure formation was measured using matrigel tubule formation assay. Representative pictures for two groups are shown. f The number of formed capillary tubes in two groups were counted. Data shown are mean ± SD from three independent experiments. ^** P < 0.01, ^*** P < 0.001