Fig. 1.

Workflow. Expression data as measured with microarrays or RNA-seq is tested for enrichment of specific functional gene sets, e.g. as defined in the Gene Ontology or the KEGG pathway annotation. Additional information from regulatory networks annotated in specific databases such as the RegulonDB or Yeastract can be exploited. Implemented methods can be carried out individually and combined by selected ranking criteria. Resulting gene set rankings can be browsed as HTML pages allowing detailed inspection (as illustrated in Fig. 2)