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. 2016 Jan 20;8:7. doi: 10.1186/s13148-016-0172-y

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© Roos et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Differential methylation with respect to time of cancer diagnosis. a Unadjusted DNA methylation values at cg02444695 (near SASH1) in affected individuals (red) and healthy co-twins (blue), shown with respect to time of diagnosis (years) with smooth (LOESS) lines fitted for both groups. The orange vertical line represents the time of diagnosis. b Methylation differences within twin pairs at the four top-ranked DMPs and cg04533633 (at COX7C). Each smooth (LOESS) line represents the methylation difference (affected − unaffected twin) at an individual probe (see legend)