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. 2016 Jan 20;8:7. doi: 10.1186/s13148-016-0172-y

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© Roos et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Functional follow-up of top-ranked pan-cancer DMPs. Adjusted whole blood DNA methylation profiles compared to adjusted gene expression levels for (a) cg21046959 in blood and ILMN_1809352 (PRL) in LCLs, and (b) cg27094856 in blood and ILMN_1701877 (AXL) in skin. Data are obtained from 283 healthy middle-aged females and lines represent the least squares regression fit. c Enrichment analysis of genomic annotation categories within the 500 top-ranked cancer DMPs. The bars indicate the difference in proportion of DMPs compared to the remainder of probes used in the study in the corresponding genomic annotation class. Nominally significant results were obtained for the ‘enhancer’ category (P = 0.03)