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. 2016 Jan 20;4:3. doi: 10.1186/s40168-016-0147-4

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© Cribbs et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Overall schema. Overall schematic that postulates that HIV infection alters metabolomic profiles in lung (inflammatory and oxidant pathways) which causes a shift in the functional properties of the lung microbiome and/or in the host response to the lung microbiome which may lead to an increased risk of lung infection or to chronic lung disease associated with HIV