A Diagrammatic representation of the impact of EPHOSS on cells and cellular processes. Abbreviations: EPHOSS, extra physiologic oxygen shock/stress; ROS, reactive oxygen species; miR, micro RNA; hif1α, hypoxia inducing factor 1α; O2, oxygen; CSA, cyclosporine A; cypD; cyclophilin D; HSC, hematopoietic stem cell; HPC, hematopoietic progenitor cell.