Table 1.
Dose (mg/kg) | Cmax (µg/ml) | AUC∞ (µg·min/ml) | t1/2 initial (min) | Vd(l/kg) | Cl (l/h/kg) |
---|---|---|---|---|---|
1 IV | 5.2 ± 0.9 | 32 ± 4.2 | 4.7 ± 0.5 | 0.17 ± 0.03 | 2.02 ± 0.36 |
5 IV | 26 ± 11 | 288 ±115 | 7.4 ± 0.9 | 0.31 ±0.14 | 2.09 ± 0.98 |
10 IV | 100 ± 21 | 1162 ± 121 | 9.0 ± 0.6 | 0.12 ± 0.01 | 0.54 ± 0.05 |
20 IV | 182 ± 56 | 4030 ± 405 | 14.0 ± 2.1 | 0.10 ± 0.03 | 0.30 ± 0.03 |
Pharmacokinetics parameters are presented as Mean ± SEM, n = 4 subjects at each dose.