Table 3.

Risk for Mortality According to Frailty Status at Baseline for all participants and stratified by sex

	All participants		Stratified analyses by Sex
	N=2355, 500 events		Women n=1173, 208 events		Men n=1182, 292 events		Interaction
	HR (95% CI)a	p-value	HR (95% CI)	p-value	HR (95% CI)	p-value	p-valueb
Frailty Indexc	1.12 (1.10, 1.15)	<0.001	1.16 (1.12, 1.20)	<0.001	1.10 (1.07, 1.13)	<0.001	0.037
Frailty Subgroup		<0.001c		<0.001c		<0.001c	0.063c
Fit	1.00 (reference)		1.00 (reference)		1.00 (reference)
At Risk	1.47 (1.03, 2.10)	0.035	1.76 (0.98, 3.16)	0.057	1.27 (0.81, 1.99)	0.30
Frail	2.65 (1.86, 3.78)	<0.001	4.18 (2.36, 7.37)	<0.001	1.87 (1.19, 2.94)	0.007
Frailest	3.91 (2.69, 5.68)	<0.001	5.26 (2.88, 9.61)	<0.001	3.15 (1.98, 5.02)	<0.001

^aAll models are adjusted for age (as the time variable), education (continuous), and sex where applicable.

^bInteraction p values for frailty* sex derived from Cox proportional hazards models.

^cEstimates or risk per 1 point increase in the continuous Frailty Index (0–36).

^cP-value for trend.