Skip to main content
PMC home page
Thorax logoLink to Thorax
. 1970 Mar;25(2):230–236. doi: 10.1136/thx.25.2.230

Pathogenesis of experimental pulmonary alveolar proteinosis

B Corrin 1,2, E King 1,2
PMCID: PMC472151  PMID: 5441994

Abstract

Rats exposed to various airborne dusts developed a condition identical to pulmonary alveolar proteinosis as seen in man. The experimental condition developed through a stage of endogenous lipid pneumonia, characterized by numerous large foamy macrophages widely distributed throughout the lung. These cells broke down to release a finely granular material which finally condensed to reproduce the appearances of alveolar proteinosis. Electron microscopy indicated that the alveolar material was produced by type II pneumocytes and may therefore represent pulmonary surfactant. A study of the dust-handling mechanism showed that in affected animals macrophage mobility was seriously impaired.

Full text

PDF
236

Images in this article

234Image
on p.234
234Image
on p.234
231Image
on p.231
232Image
on p.232
232Image
on p.232
233Image
on p.233
235Image
on p.235

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENSCH K., SCHAEFER K., AVERY M. E. GRANULAR PNEUMOCYTES: ELECTRON MICROSCOPIC EVIDENCE OF THEIR EXOCRINIC FUNCTION. Science. 1964 Sep 18;145(3638):1318–1319. doi: 10.1126/science.145.3638.1318-a. [DOI] [PubMed] [Google Scholar]
  2. BUCKINGHAM S., MCNARY W. F., Jr, SOMMERS S. C. PULMONARY ALVEOLAR CELL INCLUSIONS: THEIR DEVELOPMENT IN THE RAT. Science. 1964 Sep 11;145(3637):1192–1193. doi: 10.1126/science.145.3637.1192. [DOI] [PubMed] [Google Scholar]
  3. GROSS P., BROWN J. H. U., HATCH T. F. Experimental endogenous lipoid pneumonia. Am J Pathol. 1952 Mar-Apr;28(2):211–221. [PMC free article] [PubMed] [Google Scholar]
  4. Gough J. Silicosis and alveolar proteinosis. Br Med J. 1967 Mar 11;1(5540):629–629. doi: 10.1136/bmj.1.5540.629-b. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gross P., DeTreville R. T. Alveolar proteinosis. Its experimental production in rodents. Arch Pathol. 1968 Sep;86(3):255–261. [PubMed] [Google Scholar]
  6. Heppleston A. G. Atypical reaction to inhaled silica. Nature. 1967 Jan 14;213(5072):199–199. doi: 10.1038/213199a0. [DOI] [PubMed] [Google Scholar]
  7. Jennings I. W., Gresham G. A., Howard A. N. Pulmonary lipidosis in laboratory rats. J Reticuloendothel Soc. 1965 Jul;2(2):130–140. [PubMed] [Google Scholar]
  8. KLAUS M., REISS O. K., TO OLEY W. H., PIEL C., CLEMENTS J. A. Alveolar epithelial cell mitochondria as source of the surface-active lung lining. Science. 1962 Sep 7;137(3532):750–751. doi: 10.1126/science.137.3532.750. [DOI] [PubMed] [Google Scholar]
  9. ROSEN S. H., CASTLEMAN B., LIEBOW A. A. Pulmonary alveolar proteinosis. N Engl J Med. 1958 Jun 5;258(23):1123–1142. doi: 10.1056/NEJM195806052582301. [DOI] [PubMed] [Google Scholar]
  10. Ramirez J., Harlan W. R., Jr Pulmonary alveolar proteinosis. Nature and origin of alveolar lipid. Am J Med. 1968 Oct;45(4):502–512. doi: 10.1016/0002-9343(68)90166-6. [DOI] [PubMed] [Google Scholar]
  11. Yang Y. H., Yang C. Y., Grice H. C. Multifocal histiocytosis in the lungs of rats. J Pathol Bacteriol. 1966 Oct;92(2):559–561. doi: 10.1002/path.1700920233. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES