Skip to main content
. Author manuscript; available in PMC: 2016 Jan 21.
Published in final edited form as: Nature. 2009 Apr 29;459(7245):387–392. doi: 10.1038/nature08040

Figure 2. Antioxidant treatment rescues Bmi1–/– thymocytes.

Figure 2

a, ROS in thymocytes isolated from four-week-old wild-type (WT) mice or Bmi1–/– mice randomized to NAC treatment for one week before collection. b, Overall thymus size in 4-week-old mice either treated for one week with NAC (+) of left untreated (–). c, Total number of thymocytes recovered in 4-week-old Bmi1–/– mice either treated for one week with NAC or left untreated (mean and s.d.; n = 4 animals per group). d, Representative assessment of thymocyte maturation (CD4+CD8+ cells) in 4-week-old WT or Bmi1–/– mice that were treated with NAC for one week or left untreated before collection. e, Quantitative assessment of thymocyte maturation in 4-week-old mice randomized for one week of antioxidant treatment (mean and s.d.; n = 4 animals per group). f, Weight of Bmi1–/– mice with or without antioxidant treatment beginning after weaning (mean and s.d.; n = 5–7 animals per group). *P < 0.05.