Table 1.
Demographic and clinical characteristics of study participants in the COGS replication study
| European descent | Asian descent | African descent | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristics | Controls (n=23,447) N (%) |
Invasive Cases (n=14,525) N (%) |
p- value2 |
Controls (n=1,574) N (%) |
Invasive Cases (n=714) N (%) |
p- value2 |
Controls (n=200) N (%) |
Invasive Cases (n=150) N (%) |
p- value2 |
| Age (years) | |||||||||
| Mean ± SD | 55.6± 11.9 | 58.1± 11.3 | <.0001 | 53.5± 11.2 | 54.2± 12.1 | 0.15 | 53.3± 11.6 | 56.6± 11.4 | 0.009 |
| <40 | 2027 (8.7) | 748 (5.2) | <.0001 | 101 (6.4) | 69 (9.7) | <0.0001 | 23 (11.5) | 9 (6.0) | 0.021 |
| 40–49 | 4771 (20.6) | 2544 (17.6) | 565 (35.9) | 187 (26.2) | 56 (28.0) | 25 (16.7) | |||
| 50–59 | 7403 (31.9) | 4537 (31.3) | 459 (29.2) | 228 (32.0) | 60 (30.0) | 54 (36.0) | |||
| 60–69 | 6098 (26.3) | 4324 (29.8) | 346 (22.0) | 147 (20.6) | 41 (20.5) | 42 (28.0) | |||
| ≥70 | 2892 (12.5) | 2343 (16.2) | 103 (6.5) | 82 (11.5) | 20 (10.0) | 20 (13.3) | |||
| Family history of ovarian cancer1 | |||||||||
| No | 15425 (92.0) | 8634 (82.4) | <.0001 | 382 (61.0) | 370 (75.5) | <.0001 | 152 (91.6) | 97 (89.8) | 0.67 |
| Yes | 1351 (8.0) | 1849 (17.6) | 244 (39.0) | 120 (24.5) | 14 (8.4) | 11 (10.2) | |||
| Histological subtypes | |||||||||
| Serous | N/A | 8368 (57.6) | N/A | 249 (34.9) | N/A | 89 (59.3) | |||
| Endometroid | 2067 (14.2) | 112 (15.7) | 16 (10.7) | ||||||
| Clear Cell | 1024 (7.1) | 103 (14.4) | 6 (4.0) | ||||||
| Mucinous | 944 (6.5) | 60 (8.4) | 11 (7.3) | ||||||
| Others3 | 2122 (14.6) | 190 (26.6) | 28 (18.7) | ||||||
1
for the first degree relatives
2
t-test for a continuous variable and chi-square test for a categorical variable
3
include mixed cell, other specified epithelial, undifferentiated, unknown (but known to be epithelial)