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. 2015 Oct 13;2(1):63–76.e5. doi: 10.1016/j.jcmgh.2015.08.008

Figure 5.

Figure 5

AOM plus DSS treatment causes an increased incidence and increased size of tumors in the colorectum of Ugt1ΔIECmice compared to Ugt1F/Fmice. (A) A schematic schedule is shown as the AOM plus DSS feeding protocol. Each rectangle represents one week. (B) Photos of colon tumors in Ugt1F/F and Ugt1ΔIEC mice. (C) Representative tumor morphologies in colonic sections by H&E staining (50× and 200× magnification). The black arrow indicates the penetrating adenoma. (D) Tumor incidence and (E) size distribution in Ugt1F/F and Ugt1ΔIEC mice. At least seven mice were analyzed in each group, and results are presented as mean ± standard deviation (*P < .05, **P < .01, ***P < .001).