Table 3.
Prevalence of Respiratory Virus Detection With rRT-PCR in Asymptomatic Controls and Patients With CAP ≥18 Years Old
| Virus | Asymptomatic Adults, No. (%) (n = 238) | Adults With CAP, n (%) (n = 192) | P Valuea | aOR (95% CI)b | AF (95% CI) |
|---|---|---|---|---|---|
| Any virusc | 5 (2.1) | 47 (24.5) | <.01 | NCd | NCd |
| hRV | 2 (0.8) | 21 (10.9) | <.01 | 13.4 (3.04–59.1) | 0.93 (.67–.98) |
| RSV | 0 | 3 (1.6) | .09 | NCd | NC |
| hMPV | 1 (0.4) | 8 (4.2) | .01 | 13.5 (1.65–110) | 0.93 (.39–.99) |
| AdV | 0 | 3 (1.6) | .09 | NC | NC |
| Influenza (A and B) | 0 | 5 (2.6) | .02 | NC | NC |
| PIV (types 1–3) | 0 | 3 (1.6) | .09 | NC | NC |
| CoV (229E, HKU1, NL63, OC43) | 2 (0.8) | 6 (3.1) | .14 | 3.19 (.59–17.1) | 0.69 (−.69 to .94) |
Abbreviations: AdV, adenovirus; AF, attributable fraction; aOR, adjusted odds ratio; CAP, community-acquired pneumonia; CI, confidence interval; CoV, coronavirus; hMPV, human metapneumovirus; hRV, human rhinovirus; NC, not calculated; PIV, parainfluenza virus; rRT-PCR, real-time reverse-transcriptase polymerase chain reaction; RSV, respiratory syncytial virus.
a Univariate comparisons with P values by χ2 (count ≥5 in each cell) or Fisher exact test.
b Logistic regression model adjusted for the following variables: age, enrollment month, and enrollment site.
c The number of subjects with any viral detection does not equal the sum of detections for each virus owing to codetections of multiple viruses in the same subject.
d aOR and AF were not calculated for the “Any virus” group or for viruses with no detections among asymptomatic controls.