Table 3.
Categorization of proteins identified in C. albicans SC5314 surfome of yeast and hyphae.
| Categories | Common in Yeast and Hypha | Only identified in Yeast | Only identified in Hypha | Total |
|---|---|---|---|---|
| GPI-anchored | 17 | 2 | 9 | 28 |
| Als1, Cht2, Crh11, Ecm33, Ihd1, Pga4, Phr1, Phr2, Pir1, Plb4.5, Rbt1, Rbt5, Rhd3, Sap9, Ssr1, Utr2, Ywp1. | Als2, Sap10. | Als3, Eap1, Hyr1, Pga10, Pga45, Pga52, Pga53, Plb3, Sod5. | ||
| Cell wall organization or biogenesis | 22 | 1 | 28 | 51 |
| Act1, Agm1, Bgl2, Bmh1, Cmk2, Eng1, Gda1, Gfa1, Mnt1, Msb2, Pmi1, Ras1, Rho1, Sim1, Slk19, Sod1, Srb1, Sun41, Sur7, Tsa1, Yps7, Ypt31. | Xog1. | Arp2, Bud7, Cdc10, Chs5, Clc1, Cwh43, Dck1, End3, Flc2, Gsc1, Hog1, Kex2, Kre9, Lmo1, Mnn26, Pbs2, Pho85, Pmr1, Pmt1, Pmt2, Pmt4. Pop2, Rac1, Rvs161, Rvs167, Smi1, Snf1, Tps2. | ||
| Cell surface | 58 | 2 | 6 | 66 |
| Adh1, Atp1, Atp2, Cdc19, Cdc48, Cef3, Cht3, Coi1, Csp37, Ddr48, Efb1, Eft2, Egd2, Eno1, Fba1, Gpd2, Gph1, Gpm1, Hem13, Hsp104, Hsp21, Hsp70, Hsp90, Ino1, Kar2, Met6, Mp65, Orf19.2478.1, Pdc11, Pdi1, Pgk1, Pma1, Rbe1, Rpl10, Rpl13, Rpl14, Rpl17b, Rpl19a, Rpl20b, Rpl3, Rpl4b, Rpl6, Rps10, Rps6a, Rps7a, Rsp8a, Sam2, Scw11, Ssa2, Ssb1, Ssc1, Ssz1, Tal1, Tdh3, Tkl1, Tos1, Tpi1, Ugp1. | Fet99, Pho113. | Aip2, Cdr1, Fre10, Rax2, Rbt4, Sdh2. | ||
| Pathogenesis | 12 | 1 | 22 | 35 |
| Ade5.7, Age3, Asc1, Cdc42, Fas2, Msi3, Tfp1, Ttr1, Tup1, Vma2, Wh11, Yhb1. | Hex1. | Alo1, Cat1, Cdc11, Cla4, Crk1, Csh3, Gna1, Gpa2, Het1, Mlt1, Mts1, Nmt1, Not5, Obpa, Ole1, Rsr1, Slr1, Srv2, Ssd1, Ssn6, Vps27, Ypt72. | ||
| Stress Response | 51 | 2 | 68 | 121 |
| Ade1, Ade12, Ade13, Aha1, Ahp1, Atc1, Bcy1, Ccp1, Cdc54, Ded1, Dot5, Erf1, Erg13, Gis2, Glc7, Gln1, Glx3, Gnd1, Gre3, Hsp12, Imh3, Lsp1, Orf19.1340, Orf19.4216, Orf19.4246, Orf19.4622, Orf19.5281, Orf19.5620, Orf19.5943.1, Orf19.6358, Pet9, Pil1, Pol30, Prx1, Rdi1, Rhr2, Rpg1a, Rpl16a, Rpt4, Sbp1, Sgt2, Skp1, Smt3, Sub2, Sui2, Tma19, Trr1, Trx1, Ynk1, Ypt1, Zpr1. | Orf19.4150, Orf19.7196. | Apm1, Arf2, Bdf1, Bre1, Cct8, Cdc28, Cdc37, Cip1, Crm1, Cta3, Dhh1, Doa1, Erg1, Gea2, Gpd1, Grx3, Hat2, Hbr1, Hrr25, Hsp60, Hta1, Hta2, Lag1, Mcr1, Mxr1, Myo2, Ncb2, Orf19.2265, Orf19.2304, Orf19.239, Orf19.512, Orf19.5833, Orf19.5917.3, Orf19.6250, Orf19.6424, Orf19.7160, Orf19.86, Orf19.933, Osm2, Pob3, Ptc2, Pyc2, Rad23, Rad6, Rfa2, Rfc1, Rgd1, Rli1, Rpo21, Rp6, Sec18, Sec7, She3, Shp1, Sin3, Sis1, Spt5, Spt6, Svf1, Taf14, Tfg1, Tif34, Ura7, Vac8, Yck2, Yim1, Ypt52, Zrt2. | ||
| Plasma membrane | 23 | 1 | 64 | 88 |
| Ade17, Adh2, Cof1, Erg6, Erv25, Faa4, Glk1, Hgt6, Hgt7, Ist2, Mdg1, Met15, Orf19.1564, Orf19.6160, Orf19.6553, Pfy1, Pgi1, Pho88, Sac6, Tif, Tom22, Tom70, Ycp4. | Fet3. | Ali1, Apm4, Atp17, Atp3, Atp4, Atp7, Cbr1, Chc1, Cox13, Cox4, Cox5, Cox6, Cox9, Ctr1, Cyt1, Ddi1, Dpm1, Elf1, Emp24, Erg11, Frp3, Gap4, Gca1, Gut2, Hmg1, Hom2, Kin2, Lem3, Mir1, Nde1, Orf19.1840, Orf19.1970, Orf19.3003, Orf19.3235, Orf19.3290, Orf19.3335, Orf19.3430, Orf19.409, Orf19.4396, Orf19.4864, Orf19.5006.1, Orf19.5095, Orf19.5340, Orf19.5669, Orf19.6082, Orf19.7310, Pan1, Phm7, Por1, Pst3, Qcr2, Rho3, Rip1, Sec26, Sec4, Sec61, Sec62, Shm2, Stt3, Tcp1, Tim23, Tim50, Tom20, Vma5. | ||
| Orf's | 50 | 3 | 122 | 175 |
| Other identified proteins | 190 | 3 | 186 | 379 |
| Total | 423 | 15 | 505 | 943 |
Proteins were classified in the 8 designated categories according to Candida Genome Database (CGD) Gene Ontology (GO) terms (in parentheses the GO identifier): Cell wall organization or biogenesis (71554), cell surface (9986), pathogenesis (9405), response to stress (6950) and plasma membrane (5886). GPI-anchored category is based on Richard et al. [2]. Orf's category refers to proteins without standard name in CGD. Other identified proteins category is composed by proteins not classified in previous sections.