Figure 1. Rats judged interval durations as either long or short.

(a) Rats triggered interval stimuli (i.e. two brief auditory tones separated by a silent interval of random duration) by inserting their snout into a central port. Following interval offset, animals reported their long vs short judgment at two lateral choice ports. Correct trials yielded a water reward, while incorrect or premature responses produced a white noise sound and a time out. Top view, high-speed video was acquired throughout task performance. (b) Reward contingency. (c) Averaged psychometric curves following bilateral muscimol or saline injections in dorsal striatum (mean ± standard deviation across session means, and logistic fit; n = 3 rats, 4 sessions each). Inset: slope of psychometric curves on consecutive saline and muscimol sessions. All raw data for Figure 1 can be found in Figure 1—source data 1.

DOI: http://dx.doi.org/10.7554/eLife.11386.003

Figure 1—figure supplement 1. Histological confirmation of cannula placements.

Histology slices and schematic representation of the location of saline and muscimol injections. Coronal slices at intermediate anterior posterior (AP) positions are shown for reference at +0.84mm (left, rat Albert), +1.68 mm (center, rat Yuri) and + 0.60 mm (right, rat Zack) from Bregma. Vertical grey bars represent the location of the cannula placements. Yellow asterisks (*) show the approximate dorsal-ventral (DV) position from where the injectors extended 1.5 mm bellow the cannulae.

DOI: http://dx.doi.org/10.7554/eLife.11386.005