Table 2.

Adverse events

Patient	Operation	Response	CTCAE grading	Adverse event
1	2 × PIPAC, small bowel resection	CR	1	Abdominal pain
2	1 × PIPAC	N/A	1	CRP
3	4 × PIPAC	CR	1	CRP
4	1× PIPAC, ileostomy	N/A	3	CRP, Cholangitis
5	4 × PIPAC	PR	3	Hepatotoxicity, abdominal pain
6	2× PIPAC	SD	1	CRP
7	4× PIPAC	PD	1	CRP
8	1× PIPAC	N/A	1	Abdominal pain
9	5× PIPAC	CR	1	Abdominal pain, CRP
10	5 × PIPAC, adhesiolysis, incisional hernia repair	CR	1	Hepatotoxicity, CRP
11	4× PIPAC	PR	4	Allergy, myolysis
12	3× PIPAC, small bowel resection	PR	3	Hepatotoxicity, abdominal pain
13	3× PIPAC	CR	1	Abdominal pain, CRP
14	1× PIPAC	N/A	1	CRP
15	2× PIPAC	PR	1	CRP
16	2× PIPAC	PR	1	N/V, CRP
17	3× PIPAC	SD	1	Renal toxicity, CRP
18	2× PIPAC, gastrectomy	CR	1	CRP
19	2× PIPAC	PR	5	CRP, Hepatotoxicity, progressive SBO, death
20	1× PIPAC	N/A	3	CRP, Hepatotoxicity
21	2× PIPAC	PD	3	Hepatotoxicity
22	1× PIPAC	N/A	5	Ascites decompensation, death
23	5× PIPAC	SD	3	Hepatotoxicity, CRP, 2 × Access lesion
24	1× PIPAC	N/A	1	Access site extravasation

PIPAC pressurized intraperitoneal aerosol chemotherapy, CRS cytoreductive surgery, CTCAE Common Terminology Criteria for Adverse Events Version 4.0, CR complete remission, PR partial remission, SD stable disease, PD progressive disease, CRP C-reactive protein, RT renal toxicity, N/V nausea–vomiting, SBO small bowel obstruction