Table 1.
Overview of methods used for validation of automated tissue specific reconstruction algorithms.
| Method | Used by |
|---|---|
| Consistency testing | |
| Cross validation | PRIME, FASTCORE, MBA, FASTCORMICS, iMAT |
| Diversity of generated models | GIMME, mCADRE, tINIT, FASTCORMICS |
| Comparison based testing | |
| Comparison with manually curated network | INIT, MBA |
| Comparison with additional databases | mCADRE, RegrEx, iMAT |
| Comparison with shRNA knockdown screens | MBA, FASTCORMICS |
| Comparison with literature mining | iMAT |
| Comparison with metabolic exchange rates | PRIME |
| Comparison with known metabolic functions | MBA, mCADRE, FASTCORE |