Fig. 5. . Effects of 1-EBIO on the membrane conductance of HNSCCs pretreated with ionomycin under Ca²⁺-unclamped condition.

Left panels (A, C, E) representative current traces of HNSCCs in response to the depolarizing ramp pulses. 1 µM ionomycin, 50 µM 1-EBIO, and 5 µM TRAM-34 were applied as indicated above each trace. Right panels (B, D, F); I/V curve obtained by the ramp pulses in each cell line of HNSCCs as indicated at the corresponding left panels. The specific timing of I/V curve is indicated by the number in parenthesis. Note the weakly inward rectifying outward currents induced by 1-EBIO in SNU-1076 and OSC-19.