Skip to main content
. 2015 Dec 31;20(1):25–33. doi: 10.4196/kjpp.2016.20.1.25

Fig. 6. Membrane voltage changes in response to ionomycin, 1-EBIO and TRAM-34 in HNSCCs.

Fig. 6

Traces of membrane potential in HNSCCs obtained under zero-current clamp condition with 0.1 mM EGTA KCl pipette solution. 1 µM ionomycin, 50 µM 1-EBIO, and 5 µM TRAM-34 were applied as indicated in each panel. Representative results from more than five cells from each cell line are shown. Ionomycin alone hyperpolarized the membrane potential in SNU-1076 (A) while the combined application of 1-EBIO induces strong hyperpolarization in both SNU-1076 and OSC-19 (A, B). Final addition of TRAM-34 depolarized the membrane potential in SNU-1076 and OSC-19 (A, B). Neither ionomycin nor 1-EBIO induced significant change in the membrane potential of HN5 (C).