Fig. 6. Effects of repetitive depolarization on paroxetine-induced inhibition of Kv1.5 currents.
(A) Original current traces under control conditions and in the presence of 10 µM paroxetine obtained by applying 20 repetitive 125-ms depolarizing pulses of +50 mV from a holding potential of -80 mV at 1 and 2 Hz. The dotted lines represent a zero current. (B) Plot of normalized current at 1 and 2 Hz under control conditions (open circle and open triangle, n=4) and in the presence of 10 µM paroxetine (closed circle and closed triangle, n=4) as a function of the number of pulses. Peak amplitudes of the current from every pulse were normalized to the peak amplitudes of current obtained from the first pulse. (C) Relative current (IParoxetine/IControl) plotted at 1 (open square) and 2 Hz (closed square) from (B) as a function of the number of pulses. Data are expressed as mean±S.E.M.