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. 2015 Aug 11;39(12):1742–1749. doi: 10.1038/ijo.2015.131

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Leptin and access to food attenuates cue-induced firing. (a) The absence of cue-induced firing in dopamine (DA) and non-DA (nDA) neurons (resp. green and orange trace) following ad lib access to food. No significant difference was found between both neuron types after cue presentation (first 100 ms; insert). (b) Leptin (orange trace) attenuates cue-induced firing of DA neurons in food-restricted animals (green trace). The insert shows a significant difference between both treatments after cue presentation (first 100 ms), the control group is identical to the group shown in Figure 3a. (c) Ghrelin does not affect cue-induced firing in food-restricted animals (orange trace) compared with saline-treated animals (green trace). The insert shows the average firing activity for both conditions after cue presentation (first 100 ms), the control group is identical to the group shown in Figure 3a. All data represented as normalized z-scores. *Significant difference P<0.05. Shaded gray area represents the reward-delivery interval.