Table 1.
Test | Normal reference range | Baseline (pre-therapy) | Months while on gonadotrophin (HCG) therapy | Off gonadotrophin therapy | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
First test | Second test | 3 | 5 a | 6 | 9 | 12 | 16 | 20 a | 2 | 6 | ||
Testosterone | 10–38 nmol/l | 2.6 | 3.3 | 15.2 | – | 25.8 | 5.1 | 19.9 | 18.5 | 24.7 | 7.8 | 5.6 |
Haemoglobin | 130–180 g/l | 156 | – | 155 | – | 164 | – | 148 | – | 143 | – | – |
Haematocrit | 0.40–0.53 | 0.417 | – | 0.453 | – | 0.465 | – | 0.434 | – | 0.410 | – | – |
Prostate-specific antigen | <2.5 μg/l | – | 1.0 | 1.2 | – | 7.7 | 1.3 | 1.6 | 1.3 | – | 1.4 | 0.83 |
FSH | 1–14 U/l | <1.0 | 2.0 | – | – | – | – | – | – | – | – | 4.0 |
LH | 1–9 U/l | <1.0 | 3.0 | – | – | – | – | – | – | – | – | 5.0 |
Prolactin | 0–500 mU/l | 212 | 208 | – | – | – | – | – | – | – | – | – |
Alanine transferase | 10–60 U/l | – | 94 | 101 | – | 77 | 71 | 74 | 54 | 63 | 55 | 49 |
Semen volume | >1.4 ml | 3.0 | 3.5 | – | 4.0 | – | 4.8 | 4 | – | – | 5.5 | – |
Semen pH | >7.2 | 8.0 | 7.5 | – | 8.0 | – | 8.0 | 8.0 | – | – | – | – |
Sperm concentration | >12 million/ml | <1.0 | <1.0 | – | <1.0 | – | 9.0 | 22.0 | – | – | 3 | – |
Progressive sperm | >31% | NA | NA | – | NA | – | 14 | 40 | – | – | 23 | – |
Total motility | >38% | NA | NA | – | NA | – | 21 | 41 | – | – | 33 | – |
HCG therapy was stopped at 22 months; ‘–’, indicates test was not done; NA, indicates not available.
rFSH therapy started 5 months after the commencement of HCG therapy and then was stopped at 20 months.