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. Author manuscript; available in PMC: 2016 Jan 22.
Published in final edited form as: J Mol Endocrinol. 2015 Oct;55(2):147–158. doi: 10.1530/JME-15-0090

Figure 4. Centrosome clustering and evidence of DNA damage in cells harbouring centrosome amplification.

Figure 4

(A) Centrosome clustering in proband dermal fibroblasts, with either even (left) or uneven partitioning between spindle poles (right). Immunostaining was performed using antibodies as in Figure 3. (B) Example of an anaphase bridge and resulting micronuclei formation in proband cells. (C) DNA damage foci in the nuclei and micronuclei of proband dermal fibroblasts with centrosome amplification revealed by immunofluorescence staining using anti-γH2AX antibody.