Table 1. Results of serial oral glucose tolerance testing of the proband.

	12.7 years (no treatment)		21.3 years (no treatment)		26.4 years (metformin 1.5g/day)
Time, mins	Glucose, mmol/l	Insulin, pmol/l	Glucose, mmol/l	Insulin, pmol/l	Glucose, mmol/l	Insulin, pmol/l
−30	--	--	5.4	201	--	--
0	4.2	532	5.1	1,675	5.0	219
10	--	--	5.2	1,661	--	--
30	6.2	4,375	9.4	5,596	7.5	1,416
60	6.2	4,494	10.2	10,290	7.1	1,978
90	5.3	5,005	11.3	12,060	8.6	3,095
120	4.6	3,514	9.1	9,985	6.9	5,108
150	--	--	8.3	10,300	--	--
180	--	--	7.3	8,089	--	--
Fasting Reference Range	<5.6	<60	<5.6	<60	<5.6	<60