Table 2.
Baseline and endpoint data by treatment group
|
No intervention |
Intervention |
|||||
|---|---|---|---|---|---|---|
| Baseline | Endpoint | Change | Baseline | Endpoint | Change | |
| MACI infant attentiveness | 3·65 (1·29), n=26 | 4·19 (1·13), n=26 | 0·54 (1·77), n=26 | 3·39 (1·26), n=28 | 4·22 (1·05), n=27 | 0·81 (1·49), n=27 |
| MACI infant affect | 4·08 (1·13), n=26 | 4·84 (1·38), n=26 | 0·77 (1·73), n=26 | 4·18 (1·19), n=28 | 4·85 (1·23), n=27 | 0·67 (1·57), n=27 |
| MACI caregiver sensitive responding | 3·85 (1·19), n=26 | 4·58 (1·10), n=26 | 0·73 (1·46), n=26 | 3·68 (0·98), n=28 | 4·30 (1·20), n=27 | 0·59 (1·25), n=27 |
| MACI caregiver non-directiveness | 3·73 (1·43), n=26 | 3·92 (1·32), n=26 | 0·19 (1·90), n=26 | 3·50 (1·48), n=28 | 4·67 (1·24), n=27 | 1·19 (1·78), n=27 |
| MACI dyadic mutuality | 3·00 (1·06), n=26 | 3·46 (1·30), n=26 | 0·46 (1·63), n=26 | 2·86 (1·21), n=28 | 3·22 (1·05), n=27 | 0·37 (1·42), n=27 |
| AOSI total score | 9·08 (5·32), n=26 | 7·31 (5·83), n=26 | −1·77 (6·98), n=26 | 10·04 (4·60), n=28 | 5·93 (4·05), n=27 | −4·15 (4·67), n=27 |
| MSEL receptive raw score | 10·81 (1·86), n=26 | 15·46 (3·25), n=26 | 4·65 (3·75), n=26 | 10·43 (1·67), n=28 | 13·81 (1·75), n=27 | 3·37 (2·59), n=27 |
| MSEL expressive raw score | 10·73 (1·73), n=26 | 15·42 (2·93), n=26 | 4·69 (3·30), n=26 | 10·21 (2·17), n=28 | 14·41 (2·00), n=27 | 4·15 (2·46), n27 |
| MCDI receptive | 67% non-zero=24 | 121·8 (71·02), n=25 | .. | 44% non-zero=27 | 92·54 (83·69), n=26 | .. |
| MCDI expressive | 32% non-zero=25 | 24·6 (43·13), n=25 | .. | 22% non-zero=27 | 14·77 (22·90), n=26 | .. |
| MCDI gestures | 7·33 (4·99), n=24 | 31·04 (13·75), n=25 | 22·5 (10·18), n=24 | 6·07 (4·80), n=27 | 29·44 (12·80), n=25 | 21·96 (10·34), n=24 |
| VABS communication | 28·20 (4·47), n=25 | 30·04 (5·04), n=25 | 1·42 (4·85), n=24 | 27·93 (5·23), n=27 | 28·27 (3·74), n=26 | −0·36 (4·68), n=25 |
| VABS socialisation | 30·04 (3·38), n=25 | 43·8 (6·48), n=25 | 13·17 (4·91), n=24 | 28·59 (5·02), n=27 | 44·58 (5·90), n=26 | 15·08 (4·80), n=25 |
| GAP disengagement | 182·79 (81·59), n=25 | 171·62 (100·39), n=24 | −9·01 (83·44), n=23 | 209·74 (76·49), n=28 | 160·84 (81·75), n=26 | −50·97 (78·95), n=26 |
| ERP P100 | .. | 1·27 (1·83), n=15 | .. | .. | 0·31 (1·71), n=20 | .. |
| ERP P300 | .. | 2·57 (3·03), n=15 | .. | .. | 1·33 (3·43), n=20 | .. |
Unimputed sample data are means (SD) for available cases. Scores at baseline for the MCDI showed such severe floor effects that we report the binary (zero, >zero). At endpoint, the most incomplete variables were missing 4 of 54 values. One case with unusually low VABS communication at baseline did not complete this measure at endpoint. ERP scores were available for only 15 (58%) of 26 from non-intervention and from 20 (71%) of 28 intervention participants, due to non-compliance at wearing the sensor net (n=7), insufficient artefact-free data (n=7), or technical errors (n=5). MACI=Manchester Assessment of Caregiver-Infant interaction. AOSI=Autism Observation Schedule for Infants. MSEL=Mullen Scales of Early Learning. MCDI=MacArthur-Bates Communicative Development Inventory. VABS=Vineland Adaptive Behaviour Scales. GAP disengagement=GAP-overlap attention disengagement task. ERP=event-related-potential to speech sounds.