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Gα13 and DDR1-Par3 differentially regulate cancer cell invasion in three-dimensional collagen. Gα13 enhances the invasion of pancreatic cancer cells in three-dimensional collagen by disrupting cell-cell adhesion. In contrast, DDR1 blocks three-dimensional collagen invasion by enhancing cell-cell adhesion. Par3, which is differentially regulated by DDR1 and Gα13, can also attenuate the effects of Gα13 on three-dimensional collagen invasion by enhancing cell-cell adhesion.
